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Neither has published long-term hard-outcome data such as cardiovascular events or mortality, which is the kind of evidence that ultimately defines a metabolic drugs value
similarly proposed that high glycine content in collagen has a regulatory effect on some factors related to fat accumulation and energy consumption, such as PPAR-, -, -, and uncoupling protein type 2 (UCP2) (Reference Woo, Song and Kang50)
429 Importantly, several mechanisminformed models have now entered clinical validation, guiding trial design for targeted therapies in nonsmall cell lung cancer and other malignancies
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